Prions and protein-folding diseases
نویسندگان
چکیده
منابع مشابه
Prions: protein aggregation and infectious diseases.
Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative diseases that affect humans and a large variety of animals. The infectious agent responsible for TSEs is the prion, an abnormally folded and aggregated protein that propagates itself by imposing its conformation onto the cellular prion protein (PrPC) of the host. PrPC is necessary for prion replication and ...
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Estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. Today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. A...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2011
ISSN: 0954-6820
DOI: 10.1111/j.1365-2796.2011.02387.x